Links
ORGANIZATIONS
National Scleroderma Foundation
Scleroderma Research Foundation
The Scleroderma Education Project
ABOUT
Scleroderma Fact Sheet – Scleroderma.org
https://scleroderma.org/wp-content/uploads/2021/12/Scleroderma-Overview-and-Causes-20211127.pdf
Risk factors for and possible causes of systemic sclerosis (scleroderma)
Differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups
hcom/content/early/2023/08/14/ard-2023-224184.long
Predicting the Progression of Very Early Systemic Sclerosis: Current Insights
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484572/
Extended autoantibody panel in Turkish patients with early-stage systemic sclerosis: Coexpressions and their influences on clinical phenotypes.
I am SCL-70 & RNP positive
Using Autoantibodies and Cutaneous Subset to Develop Outcome-Based Disease Classification in Systemic Sclerosis
https://pubmed.ncbi.nlm.nih.gov/31682743/
TREATMENTS & DIAGNOSIS
State-of-the-art evidence in the treatment of systemic sclerosis
https://www.nature.com/articles/s41584-023-00909-5
Immunotherapy Strategy for Systemic Autoimmune Diseases: Betting on CAR-T Cells and Antibodies
https://www.mdpi.com/2073-4468/13/1/10
Approach to Treatment
https://www.mayoclinicproceedings.org/article/S0025-6196(13)00076-1/fulltext
Management of Systemic Sclerosis: The First Five Years
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161284/
Emerging treatments for scleroderma/systemic sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170563/
CAR T-Cell Therapy
State-of-the-art evidence in the treatment of systemic sclerosis
https://www.nature.com/articles/s41584-023-00909-5
Epidemiology and Treatment of Systemic Sclerosis in Korea
This article is chocked full of all kinds of Scleroderma info. I found it really interesting.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351407/
2021 Article on Scleroderma treatments
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170563/
Some dcSSC Patients’ Skin Issues Returned after Reducing or Ending CellCept, Study Says
https://www.sciencedirect.com/science/article/abs/pii/S0049017219300848
Zinc & Lung Fibrosis
https://www.cedars-sinai.org/newsroom/zinc-found-to-play-an-important-role-in-lung-fibrosis/
https://www.sciencedaily.com/releases/2021/01/210119122030.htm
NAD+ Nicotinamide Riboside: Benefits, Side Effects and Dosage
Study author John Varga, M.D., division chief of rheumatology at Michigan Medicine
https://www.healthline.com/nutrition/nicotinamide-riboside
IL-6 trans-signaling in a humanized mouse model of scleroderma
Genentech’s Actemra Becomes the First Biologic Therapy Approved by the FDA for Slowing the Rate of Decline in Pulmonary Function in Adults With Systemic Sclerosis-Associated Interstitial Lung Disease
https://www.gene.com/media/press-releases/14897/2021-03-04/genentechs-actemra-becomes-the-first-bio
Actemra – Tocilizumab in systemic sclerosis treatment: a case report
Progressive lung damage in SSc eased by Actemra
https://www.sciencedirect.com/science/article/pii/S1521661623004588
U of A team uncovers new biological marker for scleroderma – Simple blood test can predict who will get severe disease
Complementary therapies for patients with systemic sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922560/
RAYNAUD’S & HANDS
The Scleroderma Hand: Manifestations of Disease and Approach to Management
https://www.jhandsurg.org/article/S0363-5023(17)31450-8/fulltext
Analysis of Hand Function, Upper Limb Disability, and Its Relationship with Peripheral Vascular Alterations in Raynaud’s Phenomenon
Hand Impairment in Systemic Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176259/
What Is Sclerodactyly?
Mentions UVA1
https://www.healthline.com/health/sclerodactyly
UVA1 a promising approach for scleroderma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622270/
UVA1 phototherapy
Mentions a treatment schedule
https://dermnetnz.org/topics/uva1-phototherapy
BONES
Osteoporosis Medication Raloxifene May Be Effective for Scleroderma
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02987-w
ENT
Hearing Loss
Hearing Loss & Scleroderma
https://pubmed.ncbi.nlm.nih.gov/29860565/
Hearing Loss and Diffuse Scleroderma
https://pubmed.ncbi.nlm.nih.gov/21916804/
Oral Submucous Fibrosis & Scleroderma
https://assets.cureus.com/uploads/review_article/pdf/143967/20230901-12487-1udc1dq.pdf
The Effects of Scleroderma on Voice and Swallowing
http://myentdoctor.com/2019/06/07/the-effects-of-scleroderma-on-voice-and-swallowing/
Audiovestibular Symptoms in Systemic Autoimmune Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120292/
Audiovestibular Manifestations in Patients with Primary Raynaud’s Phenomenon and Raynaud’s Phenomenon Secondary to Systemic Sclerosis
https://pubmed.ncbi.nlm.nih.gov/37176671/
PAH & CARDIO
Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483220/
Pulmonary Hypertension in Scleroderma
https://www.uofmhealth.org/conditions-treatments/rheumatology/pulmonary-hypertension-scleroderma
Scleroderma-Associated Pulmonary Arterial Hypertension: Early Detection of Better Outcome
https://pubmed.ncbi.nlm.nih.gov/35015412
Cardiac manifestations of systemic sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176808/
Systemic Scleroderma: Review and Updated Approach and Case Description to Addressing Pulmonary Arterial Hypertension and Idiopathic Pulmonary Fibrosis – A Dual Challenge in Treatment.
Systemic sclerosis: the heart of the matter
LUNGS
Esophageal dilatation and interstitial lung disease in systemic sclerosis: A cross-sectional study☆
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500283/
Bronchiectasis
https://my.clevelandclinic.org/health/diseases/21144-bronchiectasis
Protein-protein interactions linked to pulmonary involvement in SSc
https://www.sciencedirect.com/science/article/abs/pii/S1043466623000613
Radiologic approach to CTD-ILD
Effect of progressive pulmonary fibrosis on patients with CTD associated ILD
https://link.springer.com/content/pdf/10.1007/s10238-023-01212-z.pdf
DIGESTIVE SYSTEM
A Gut Feeling: The Microbiome and Scleroderma
https://www.sruk.co.uk/about-us/news/gut-feeling-microbiome-and-scleroderma/
How the western diet and gut bacteria can lead to scarring, vessel damage in scleroderma
John Varga, M.D., division chief of rheumatology at Michigan Medicine
COVID & VACCINES
Scleroderma and the Covid Vaccine
https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-023-00362-x
Covid Triggers Autoimmune Diseases
Things we’ve learned from Covid vaccines
Similarities between COVID-19 and systemic sclerosis early vasculopathy: A “viral” challenge for future research in scleroderma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280663/
FOR FUTURE REFERENCE
The Anatomic Distribution of Skin Involvement in Patients with Incident Chronic Graft-versus-Host Disease
Older but interesting.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546305/
INTERESTING MISC
The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge.
https://ehp.niehs.nih.gov/doi/10.1289/ehp.110-1240833
Absorption and effects of 3-(N-phenylamino)-1,2-propanediol esters in relation to toxic oil syndrome
https://pubmed.ncbi.nlm.nih.gov/11768157/
Review Article Toxic Oil Syndrome: Review of Immune Aspects of the Disease
https://www.tandfonline.com/doi/full/10.1080/15476910590960143
Innate Immune Modulation Induced by EBV Lytic Infection Promotes Endothelial Cell Inflammation and Vascular Injury in Scleroderma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089375/
Combinations of scleroderma hallmark autoantibodies associate with distinct clinical phenotypes
I am SCL70 and RNP positive
https://www.nature.com/articles/s41598-022-15062-4
JUST WONDERING
Ivermectin vs Quercetin vs Hydroxychloroquine: What’s the Difference?
https://covid19.onedaymd.com/2021/08/ivermectin-vs-quercetin-vs.html
Guillain-Barre syndrome could be related to Zika virus
https://www.mayoclinic.org/diseases-conditions/guillain-barre-syndrome/symptoms-causes/syc-20362793
Darwin’s Tubercle: Review of a Unique Congenital Anomaly